Available Technologies

Technologies available for license can be browsed by category below. Please contact us for more information on partnering with SIU or licensing available technologies or processes.


Agriculture’s status as the primary economic driver for southern and central Illinois is reflected in SIU’s strong agricultural research programs. SIU agricultural innovations span from engineering healthier soybeans to making crops more drought-resistant. Select agricultural technologies are featured below. Contact us for more information on partnering with SIU or licensing available technologies or processes.

  • gdhA Gene Expression to Increase Infection Resistance in Plants
    • Issued 2/26/2013 as US Pat #8,383,887

      Inventors: Ahmad Fakhoury and David Lightfoot

      Summary: Expression of the gdhA gene is used to increase the resistance of plants (such as soybean, solanacea, brassicacea, and maize) to root and ear rots. Specifically, this technology encompasses methods to control root rot and aflatoxin-producing ear rot in crop plants infected by Fusarium virguliforme and Aspergillus flavus, respectively. The technology also includes a screening method to confirm gdhA expression in plants.

  • Recombinant Eimeria Maxima Protein Delivered as Nanoparticles
    • Filed 1/12/2018 as US Prov Pat App #62/616,503

      Inventors: Vjollca Konjufca and Mark C. Jenkins

      Summary: A nanoparticle vaccine to protect poultry against Eimeria maxima, one of several Eimeria pathogens that cause coccidiosis in poultry. Conjugation of recombinant E. maxima protein EmaxIMP1 to polystyrene nanoparticles results in protection of immunized poultry as measured by weight gain. Coccidiosis is ubiquitous in poultry houses, costing the industry billions each year in bird morbidity and mortality. This is a joint technology with the USDA.
    • Extended Technology Summary [PDF]
  • Soybean Genes Resistant to Cyst Nematode and Sudden Death Syndrome
    • Issued 3/8/2011 as US Pat #7,902,337

      Inventors: David A. Lightfoot and Khalid Meksem

      Summary: A genetic marker associated with soybean resistance to cyst nematodes and sudden death syndrome is identified, as are a method for identifying resistance, a method for detecting a nucleic acid molecule that encodes this resistance, and a relevant recombinant host cell and assay kit.

  • Soybean Resistant to Cyst Nematodes
    • Issued 8/23/2018 as US Pat #10,070,614 and filed 3/18/2014 as US Pat App #14/218,669 and 8/9/2018 as US Pat App #16/059,570 with complementary filings in Brazil and China

      Inventors: Khalid Meksem, Shiming Liu, Pramod Kaitheri Kandoth, and Melissa G. Mitchum

      Summary: A transgenic soybean resistant to soybean cyst nematode and related DNA constructs, including serine hydroxymethyltransferase proteins such as GmSHMT. This technology also encompasses GmSHMT alleles with R130P and Y358 mutations and methods for breeding and analyzing plants containing these alleles.

  • Wireless Multi-Band Photodiode Sensor
    • Issued 9/27/2016 as US Pat #9,451,745

      Inventors: Susan O'Shaughnessy, Steven Evett, Martin Hebel, and Paul Colaizzi

      Summary: A multi-band photodiode sensor capable of measuring plant canopy multi-spectral reflectance and temperature is coupled with spectral analysis processes to detect plant stress such as water deprivation or disease. This technology is able to isolate soil background signatures to improve sensitivity and utility. This is a joint technology with the USDA.

Electronic and Computer-Based

In computer science, electrical and computer engineering, and myriad other disciplines, SIU's faculty, staff, and student researchers are developing novel algorithms, apps, and other computer-based tools and innovations. Select computer-based technologies are featured below. Contact us for more information on partnering with SIU or licensing available technologies or processes.

  • Binary Delta-Sigma Modulator
    • Issued 4/8/2008 as US Pat #7,355,538

      Inventors: Mohammad R. Sayeh and Azad Siahmakoun

      Summary: High-speed analog-to-digital conversion with an all-optical or all-electronic device for faster and more reliable signal processing with higher oversampling frequencies. Also includes a method for converting a continuous-time signal to a binary signal.  This is a joint technology with Rose-Hulman Institute of Technology.

  • Bi-Stable Device with Negative Delay
    • Issued 10/31/2017 as US Pat #9,806,697

      Inventors: Mohammad Sayeh, Nima Davoudzadeh, and Mohamad Tafazoli

      Summary: A bi-stable electrical or optical device utilizes the characteristic of reverse hysteresis (proteresis) to reduce switching speeds and increase oscillation rates. This device can be implemented in integrated circuits using conventional components.

    • Extended Technology Summary [PDF]
    • Video Spotlight
  • Compressive Image Sensor with Sparse Measurement Matrix
    • Filed 09/07/2017 as US Pat App #15/698,236

      Inventors: Stefan Leitner, Haibo Wang, and Spyros Tragoudas

      Summary: A compressive image sensor technique for improved capture of natural images. The technique utilizes sparse measurement matrices that eliminate the need for the complex random or pseudo-random generation components found in existing state-of the art technologies. Improved image quality is achieved with lower power requirements and fewer potential failure modes than these existing technologies.

    • Extended Technology Summary [PDF]
    • Video Spotlight
  • Computationally Distinguishing Handwritten Pencil Marks from Preprinted Marks in a Scanned Document
    • Issued 4/28/2015 as US Pat #9,019,570

      Inventors: Randal Fry, Raghuveer Kanneganti, Ahmed Fadhil, and Lalitmore Gupta

      Summary: Image processing operations and a pattern recognition algorithm are coupled with a multivariate Gaussian classifier to distinguish graphite marks from other markings using low-cost visible light scanners.  This is a joint technology with McGraw-Hill.

  • Digital Potentiostat Circuit and System
    • Issued 9/30/2014 as US Pat #8,845,870

      Inventors: Brad Noble and Mike Shaw

      Summary: This technology relates to a circuit and system for an inexpensive digital potentiostat that provides precision and accuracy in electrochemical analysis. A number of companies manufacture potentiostat instruments that deliver high precision and accuracy at an equally high cost which makes them inaccessible for mass use purposes such as classroom use. Low cost potentiostats exist but their precision and accuracy is poor. This technology provides a low cost solution that requires precision and accuracy that is unmet by the present commercially available potentiostats.

  • Double-Node Upset Tolerant Electrical Latch
    • Issued 9/25/2018 as US Pat #10,084,435 and filed 8/23/2018 as US Pat App #16/110,137

      Inventors: Adam Watkins and Spyros Tragoudas

      Summary: An electrical latch that eliminates radiation-induced errors affecting up to two nodes/transistors. The device features 4x shorter processing delays and has fewer components than state-of-the-art double-node upset tolerant latches, allowing for lower power usage, a smaller physical footprint, and fewer failure modes. This technology has applications in the field of radiation-hardened electronics, including circuitry for space satellites, nuclear facility equipment, and radiation detection and monitoring equipment.

    • Extended Technology Summary [PDF]
  • Higher-Order Complex Threshold Logic Gates
    • Filed 3/13/2018 as US Prov Pat App #62/642,366

      Inventors: Themistoklis Haniotakis, Spyros Tragoudas, and Seyed Nima Mozaffari

      Summary: A design for current-mode logic gates featuring higher-order threshold functions; that is, circuits for which the relationship between inputs and weights need not be one to one. For complex functions, this additional degree of freedom can allow for a gate to be constructed with fewer components to allow for faster, more efficient operation, a smaller physical footprint, and fewer potential failure modes. An accompanying automation framework allows for the efficient identification of such circuits.

    • Extended Technology Summary [PDF]
  • Multicast Routing Protocol for Computer Networks
    • Issued 10/4/2016 as US Pat #9,461,832

      Inventors: Bidyut Gupta, Sindoora Koneru, and Shahram Rahimi

      Summary: A means for improving bandwidth utilization for multi-user/group communication using Distance Vector Routing (DVR) information and Reverse Path Forwarding (RPF). Applications include video conferencing, distance learning, social networking, battlefield communications, and more

Energy & Environment

Once a pillar of the US coal industry, southern and central Illinois have strong roots in the energy sector. Today, SIU scientists and engineers are developing cleaner, safer, and more sustainable energy innovations. Select energy technologies are featured below. Contact us for more information on partnering with SIU or licensing available technologies or processes.

  • Automated System for Coal Spiral
    • Issued 9/8/2015 as US Pat #9,126,205

      Inventors: Manoj Mohanty, Ajay Mahajan, and Baojie Zhang

      Summary: A device that converts a conventional coal spiral to an electrically automated system capable of adjusting splitter position to optimize spiral performance under changing operating conditions. The retrofit apparatus includes a sensor and a microprocessor-controlled servo or gear motor.

  • Bacteriocin Based Methods to Control Lactic Acid Bacterial Growth
    • Issued 10/22/2013 as US Pat #8,563,293

      Inventor: Ronald Worthington

      Summary: The present invention relates to antibacterial proteins, bactericidal organisms expressing antibacterial proteins, and methods of use. This technology limits or eliminates bacterial contamination without the use of antibiotics, where the use of antibiotics are not cost prohibitive, and do not cause harm to the environment or potentially cause antibiotic resistant bacteria.

  • Bacteriophage Derived Methods to Control Lactic Acid Bacterial Growth
    • Issued 3/25/2014 as US Pat #8,679,821

      Inventor: Ronald Worthington

      Summary: This technology relates to novel antibacterial proteins and nucleic acid sequences. Specifically, the invention defined in the above referenced patent includes antibacterial protein compositions, methods of use, and transgenic organisms encompassing the antibacterial proteins.

  • Spray System for Longwall Shearer Dust Control
    • Issued 11/7/2017 as US Pat #9,810,067

      Inventors: Yoginder P. Chugh, Harrold Gurley, and John Pulliam

      Summary: A liquid spray system for longwall shearer mining machines that creates an envelope to contain or neutralize dust generation. Improves air quality and worker health and safety in coal and other mining applications by reducing respirable dust.

  • Synthesis of Metal Borides
    • Issued 7/7/2015 as US Pat #9,073,758

      Inventors: Rasit Koc, Jennifer R. Mawdsley, and John David Carter

      Summary: Method for preparing carbon-coated precursors to be used for producing metal borides, including lighter-weight metal borides, at low cost. These materials can be used in bipolar fuel cell plates and other electronic, aerospace, and energy applications.

  • Water Sprays for Dust Control on Mining Machines
    • Issued 3/17/2015 as US Pat #8,979,212

      Inventor: Yoginder P. Chugh

      Summary: A spray system designed for continuous mining machines reduces coal and quartz dust by up to 35% through the use of hydraulic (water or air) “curtains.” Spray nozzles located on the mining machine chassis target dust generation and transport zones to reduce airborne dust particles sized 10 microns or less. This technology contributes to improved worker safety by improving visibility and reducing the respirable particles that can cause black lung disease and other health problems.

Medicine & Health

With more than 100 research laboratories at SIU School of Medicine and vibrant life science and biomedical engineering research communities at SIU’s Carbondale and Edwardsville campuses, SIU fosters important medical discoveries and innovations. Select medical technologies are featured below. Contact us for more information on partnering with SIU or licensing available technologies or processes.

  • ARL-1 Specific Antibodies
    • Issued 2/14/2012 as US Pat #8,114,606

      Inventor: Deliang Cao

      Summary: This invention relates to antibodies specific for proteins differentially expressed in normal and tumor or precancerous cells and tissues. The invention more specifically relates to antibodies that are immunologically specific for a particular human protein, ARL-1 (also referred to as AKR1B10), a species of protein in the aldo-keto reductase (AKR) superfamily. The invention particularly relates to polyclonal antisera, monoclonal antibodies and fragments and derivatives thereof that are immunologically specific for ARL-1 differentially expressed in normal and tumor or precancerous cells and tissues of the gastrointestinal tract.

    • Extended Technology Summary [PDF]
  • ARL-1 Specific Antibodies and Uses Thereof
    • Issued 4/1/2014 as US Pat #8,685,666

      Inventor: Deliang Cao

      Summary: ARL-1 expression can be detected in certain normal tissues or certain cancerous tissues, particularly in human gastrointestinal tissues (such as stomach, small intestine or colon), liver, lung, breast, or prostate, using an ARL-1-specific antibody. Thus, the invention provides methods for detecting ARL-1 protein in a normal or cancerous tissue sample, particularly a liver, lung, breast, or prostate tissue sample.

    • Extended Technology Summary [PDF]
  • Dental Repair Material
    • Issued 5/7/2013 as US Pat #8,436,071

      Inventors: John Hatton, Benjamin Ber, and Gregory Steward

      Summary: This technology relates to the surprising discovery that the addition of divalent-cationic halogen salt and derivatives of cellulose polymers to dental repair compounds results in dental repair compositions having improved handling properties, which enables more effective treatment of various indications of use. Those improved handling properties include increased viscosity and shortened setting time.

  • Genetic Selection System for Identification of microRNA Target Genes
    • Issued 10/7/2014 as US Pat #8,852,926

      Inventors: Yin-Yuan Mo and Fangting Wu

      Summary: miRNA target determination largely relies on computer-aided algorithms based on the nucleotide base pairing of a miRNA sequence and the 3’-untranslated regions of a potential target gene. However, predicted targets vary from one program to another. Recent evidence also indicates that even perfect base pairing may not predict miRNA-target interactions. This novel system utilizes a specially constructed plasmid that contains a puromycin resistance gene, a resistance gene blocker, and cDNA for a gene of interest. The plasmid is transfected into host cells along with a vector expressing a miRNA. If the cDNA contains a miRNA target, the cells will live in the presence of puromycin. If the cDNA does not contain a miRNA target, the cells will die in the presence of puromycin. This method can be used with cDNAs and miRNAs of interest as a rapid screening tool that provides clear and measurable results. This invention could be sold either as individual plasmids or a kit and would save researchers weeks to months performing individual target validation tests.

    • Extended Technology Summary [PDF]
  • Heterogeneous Catalysts for NMR/MRI Enhancement via SABRE
    • Issued 7/18/2017 as US Pat #9,707,550

      Inventors: Boyd Goodson, Eduard Chekmenev, Fan Shi, and Aaron Coffey

      Summary: Catalysts to enhance the signal of nuclear magnetic resonance imaging using the Signal Amplification by Reversible Exchange technique. Catalysts can be injected into a patient, organism, or biological tissue to enhance signals by several orders of magnitude, allowing for faster, more accurate imaging using lower-cost imaging equipment.

  • Magnetic Induction System for Penile Prosthesis
    • Filed 11/21/2016 as US Pat App #15/357,793

      Inventors: Alberto Colombo and Kevin McVary

      Summary: A means of effecting the operation of a novel penile prosthesis through a magnetic induction device is provided by this invention. The novel penile prosthesis leverages a memory shape alloy that needs to be heated to transform its shape. The heat may be induced with the correct metal and distance to the metal.

  • Method for Creating Hyperpolarization at Microtesla Magnetic Fields
    • Filed 10/28/2015 as US Pat App #14/925,507 and 5/12/2018 as Int Pat App #PCT/US2018/032485

      Inventors: Warren Warren, Thomas Theis, Eduard Chekmenev, Milton Truong, Aaron Coffey, Boyd Goodson, and Fan Shi

      Summary: Hyperpolarization allows for enhanced magnetic imaging of patients, organisms, or biological tissue using greatly reduced magnetic field strength. This enhancement allows for faster, more accurate imagine using lower-cost equipment.

  • Methods for Diagnosing Bowel Disease
    • Issued 10/8/2013 as US Pat #8,551,720

      Inventor: Deliang Cao

      Summary: Gastrointestinal diseases, including inflammation and malignance, affect millions of people. For example, chronic ulcerative colitis and Crohn's disease affect roughly two million Americans and are often associated with the development of colorectal cancer. A determination may be made as to whether the sample comprises a bowel disease (“BD”) marker such as AKR1B10 and as to whether a patient may have a predisposition to a bowel disease using this invention.

    • Extended Technology Summary [PDF]
  • Novel Syringe System for Fluid Separation
    • Filed 7/10/2017 as US Pat App #15/645,657

      Inventors: Ashim Gupta, Sohyung Cho, and Michael Neumeister

      Summary: A syringe system for fat grafting is provided for separating fat cells from a debris layer and an oil layer efficiently and safely. The system prevents damage to the fat cells and reduces the time a patient spends in the operating room, reducing costs for the patient and optimizing the time spent by the surgeon and his/her staff.

    • Extended Technology Summary [PDF]
  • Penile Prosthesis
    • Issued 12/8/2015 as US Pat #9,204,966 (owned by Northwestern University, but jointly administered with SIU)

      Inventors: Brian Le, David Dunand, Alberto Colombo, and Kevin McVary

      Summary: This invention relates to a novel penile prosthesis that utilizes a memory shape alloy to assist with erectile dysfunction.  The prosthesis is implanted into the corpus cavernosum to expand cross-sectionally and straighten to the erect position before or during sexual intercourse.    

  • pH-Sensitive Imaging Agents
    • Issued 6/20/2017 as US Pat #9,682,157

      Inventors: Yong Gao and Boyd Goodson

      Summary: Surface-functionalized SPION-based agents allow for pH-sensitive contrast in magnetic resonance imagine applications. These agents feature a paramagnetic core, a linker group, and a macromolecule with pH sensitivity. A method for imaging biological tissue using such compounds is also addressed.

    • Extended Technology Summary [PDF]
  • Somatostatin Receptor Type 4 Agonist Compounds for Alzheimer's Disease
  • Thermoablation Probe
    • Filed 10/28/2016 as US Pat App #15/336,887

      Inventors: Jenna Gorlewicz, Eric Leuthardt, and Mahmood Rezapour

      Summary: This technology comprises a thermoablation probe for performing an interstitial thermal therapy (ITT) procedure on a brain lesion. This technology solves the problem of treating peripheral regions of the lesion that are offset from the linear path of deployment beyond the range of the probe’s radiant energy.

  • Tuning CRISPR/Cas9 Activity with Chemically Modified Nucleotide Substitutions
    • Filed 9/22/2017 as Int Pat App #PCT/US2017/053041

      Inventors: Keith Gagnon and Masad Damha

      Summary: Cleavage efficiency, kinetics and stability of CRISPR-Cas9 are tuned by chemical modification of RNA nucleotides in the ribonucleoprotein complex. Selection of appropriate modifications and substitution positions can significantly increase cleavage activity, specificity and rates and also eliminate the need for RNA bases while maintaining cleavage. This invention allows for precise control over the activity of CRISPR-Cas enzyme systems. Certain chemical modifications can substantially reduce the cost of RNA synthesis and implementation of CRISPR-Cas editing technologies while also enabling practical use in therapeutic applications.

  • Water Solubule Catalysts for NMR/MRI Enhancement
    • Issued 10/17/2017 as US Pat #9,790,245

      Inventors: Eduard Chekmenev, Boyd Goodson, Milton Truong, Ping He, Quinn Best, Fan Shi, Kirsten Groome, and Aaron Coffey

      Summary: Water-soluble catalysts to enhance the signal of nuclear magnetic resonance imaging in biological media. Catalysts can be injected into a patient, organism, or biological tissue to enhance signals by several orders of magnitude, allowing for faster, more accurate imaging using lower-cost imaging equipment.


SIU's innovative faculty, staff, and student researchers include world-class experts in hundreds of distinct research areas. Select technologies are featured below. Contact us for more information on partnering with SIU or licensing available technologies or processes.

  • Alpha-Cyano-4-Hydroxy-3-Iodocinnamic Acid as a Matrix in MALDI Mass Spectrometry
    • Filed 11/30/2017 as US Prov Pat App #62/592,775

      Inventors: Kristopher M. Kirmess, Gary R. Kinsel, and Kyle N. Plunkett

      Summary: A novel MALDI matrix adapted from the standard CHCA molecule allows for increased analyte ion signals and lower relative standard deviations as compared to CHCA.
  • Explosives Detection Via Fluorescent Organic Nanofibrils
    • Issued 4/10/2012 as US Pat #8,153,065

      Inventors: Ling Zang, Jeffrey Moore, Tammene Naddo, and Wei Zhang

      Summary: Vapor from explosives and other volatile organic compounds can be sensed via quenching of the fluorescence of a film of organic nanofibrils. A production method for scaffold synthesis and approach for optimization of molecular arrangement along the nanofibril length are also included.  This is a joint technology with the University of Illinois.

  • Method for Fractioning Peptides and Other Compounds
    • Issued 3/27/2012 as US Pat #8,143,571

      Inventors: Daniel Dyer and Gary Kinsel

      Summary: Method for selectively isolating a desired fraction of a mixed sample using a polymer brush and polymer chain. Can be used to enhance matrix-assisted laser desorption ionization mass spectrometry (MALDI MS) analysis.

  • Nano-Reagents with Cooperative Catalysis and Their Uses in Multiple Phase Reactions
    • Issued 5/31/2011 as US Pat #7,951,744

      Inventor: Yong Gao

      Summary: This technology encompasses nano-reagent catalysts, their synthesis, and methods of their use. Specifically, nanoparticles are modified with amino acids featuring reactive side chains. This catalyst, which can utilize metal oxide nanoparticles instead of precious metals, can catalyze biological reactions normally driven by enzymes. Use of a magnetic nanoparticle allows for straightforward separation of the catalyst from reaction products to allow for recovery and reuse.

  • Oxidation Protection of Carbon-Carbon Composites with Glass-Based Ceramics
    • Issued 7/12/2016 as US Pat #9,388,087

      Inventor: Jarlen Don

      Summary: Glass-ceramic coating materials with improved density and reduced porosity protect carbon-carbon materials from oxidation. The coatings are derived from heat-treated liquid precursors and have applications in aircraft and other brakes.

  • Phase-Preserving Amplifier for a Stellar Interferometer
    • Issued 12/26/2006 as US Pat #7,154,608

      Inventor: Jack Glassman

      Summary: This technology relates to the use of Optical Parametric Amplification to boost the signal strength in each of the “arms” of a stellar interferometer. After light is collected by the telescopes, it is amplified in one or more crystals pumped by one or more lasers. The signals are combined and interferograms are created with much higher signal to noise ratios than would have been possible otherwise. The wavelength amplified can be selected by adjusting the angle made between the pump and seed beams and the crystal axis. Pulsed operation allows the system to be insensitive to atmospheric turbulence.

  • Silaanthracene Compounds for Red or Near-Infrared Sensors, Probes, Dyes, and Tags
    • Issued 8/30/2016 as US Pat #9,429,568

      Inventors: Daniel Dyer, Colleen Scott, Matthew McCarroll, Lichang Wang, Narsimha Sattenapally, Quinn Best, and Denise DeAnne Dyer

      Summary: A non-toxic, biocompatible silaanthracene compound with an absorbance peak of greater than 600 nm is used as a fluorophore probe. Applications include fluorescence microscopy, in vivo imaging, flow cytometry, fluorescence correlation spectroscopy, enzyme-linked immunosorbent assays (ELISA), and dye tracing.

  • Wire Connector Driver
    • Issued 7/22/2008 as US Design Pat #D573,426

      Inventors: Bruce DeRuntz and Christopher DeRuntz

      Summary: Design for a wire nut driver with several features to enhance performance and flexibility.

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