Available Technologies

Technologies available for license can be browsed by category below. Please contact us for more information on partnering with SIU or licensing available technologies or processes.


Agriculture’s status as the primary economic driver for southern and central Illinois is reflected in SIU’s strong agricultural research programs. SIU agricultural innovations span from engineering healthier soybeans to making crops more drought-resistant. Select agricultural technologies are featured below. Contact us for more information on partnering with SIU or licensing available technologies or processes.

  • gdhA Gene Expression to Increase Infection Resistance in Plants
    • Issued 2/26/2013 as US Pat #8,383,887

      Inventors: Ahmad Fakhoury and David Lightfoot

      Summary: Expression of the gdhA gene is used to increase the resistance of plants (such as soybean, solanacea, brassicacea, and maize) to root and ear rots. Specifically, this technology encompasses methods to control root rot and aflatoxin-producing ear rot in crop plants infected by Fusarium virguliforme and Aspergillus flavus, respectively. The technology also includes a screening method to confirm gdhA expression in plants.

    • Extended Technology Summary [PDF]
  • Recombinant Eimeria Maxima Protein Delivered as Nanoparticles
    • Filed 1/11/2019 as US Pat App #16/245,773

      Inventors: Vjollca Konjufca and Mark C. Jenkins

      Summary: A nanoparticle vaccine to protect poultry against Eimeria maxima, one of several Eimeria pathogens that cause coccidiosis in poultry. Conjugation of recombinant E. maxima protein EmaxIMP1 to polystyrene nanoparticles results in protection of immunized poultry as measured by weight gain. Coccidiosis is ubiquitous in poultry houses, costing the industry billions each year in bird morbidity and mortality. This is a joint technology with the USDA.

    • Extended Technology Summary [PDF]
  • Soybean Genes Resistant to Cyst Nematode and Sudden Death Syndrome
    • Issued 3/8/2011 as US Pat #7,902,337

      Inventors: David A. Lightfoot and Khalid Meksem

      Summary: A genetic marker associated with soybean resistance to cyst nematodes and sudden death syndrome is identified, as are a method for identifying resistance, a method for detecting a nucleic acid molecule that encodes this resistance, and a relevant recombinant host cell and assay kit.

  • Soybean Resistant to Cyst Nematodes
    • Issued 9/11/2018 as US Pat #10,070,614 and issued 5/21/2019 as US Pat  #10,294,489 and filed 8/9/2018 as US Pat App #16/059,570

      Inventors: Khalid Meksem, Shiming Liu, Pramod Kaitheri Kandoth, David Lightfoot, and Melissa G. Mitchum

      Summary: Transgenic soybeans resistant to soybean cyst nematode and related DNA constructs, including mutations in serine hydroxymethyltransferase (GmSHMT) and soluble NSF-attachment protein (SNAP) that confer resistance. This technology also encompasses resistant GmSHMT and SNAP alleles and methods for breeding and analyzing plants containing these alleles.

    • Extended Technology Summary [PDF]
  • Wireless Multi-Band Photodiode Sensor
    • Issued 9/27/2016 as US Pat #9,451,745

      Inventors: Susan O'Shaughnessy, Steven Evett, Martin Hebel, and Paul Colaizzi

      Summary: A multi-band photodiode sensor capable of measuring plant canopy multi-spectral reflectance and temperature is coupled with spectral analysis processes to detect plant stress such as water deprivation or disease. This technology is able to isolate soil background signatures to improve sensitivity and utility. This is a joint technology with the USDA.

    • Extended Technology Summary [PDF]

Electronic and Computer-Based

In computer science, electrical and computer engineering, and myriad other disciplines, SIU's faculty, staff, and student researchers are developing novel algorithms, apps, and other computer-based tools and innovations. Select computer-based technologies are featured below. Contact us for more information on partnering with SIU or licensing available technologies or processes.


Energy & Environment

Once a pillar of the US coal industry, southern and central Illinois have strong roots in the energy sector. Today, SIU scientists and engineers are developing cleaner, safer, and more sustainable energy innovations. Select energy technologies are featured below. Contact us for more information on partnering with SIU or licensing available technologies or processes.

  • Bacteriophage Derived Methods to Control Lactic Acid Bacterial Growth
    • Issued 3/25/2014 as US Pat #8,679,821

      Inventor: Ronald Worthington

      Summary: This technology relates to novel antibacterial proteins and nucleic acid sequences. Specifically, the invention defined in the above referenced patent includes antibacterial protein compositions, methods of use, and transgenic organisms encompassing the antibacterial proteins.

  • Spray System for Longwall Shearer Dust Control
    • Issued 11/7/2017 as US Pat #9,810,067

      Inventors: Yoginder P. Chugh, Harrold Gurley, and John Pulliam

      Summary: A liquid spray system for longwall shearer mining machines that creates an envelope to contain or neutralize dust generation. Improves air quality and worker health and safety in coal and other mining applications by reducing respirable dust.

    • Extended Technology Summary [PDF]
  • Synthesis of Metal Borides
    • Issued 7/7/2015 as US Pat #9,073,758

      Inventors: Rasit Koc, Jennifer R. Mawdsley, and John David Carter

      Summary: Method for preparing carbon-coated precursors to be used for producing metal borides, including lighter-weight metal borides, at low cost. These materials can be used in bipolar fuel cell plates and other electronic, aerospace, and energy applications.

Medicine & Health

With more than 100 research laboratories at SIU School of Medicine and vibrant life science and biomedical engineering research communities at SIU’s Carbondale and Edwardsville campuses, SIU fosters important medical discoveries and innovations. Select medical technologies are featured below. Contact us for more information on partnering with SIU or licensing available technologies or processes.

  • ARL-1 Specific Antibodies
    • Issued 2/14/2012 as US Pat #8,114,606

      Inventor: Deliang Cao

      Summary: This invention relates to antibodies specific for proteins differentially expressed in normal and tumor or precancerous cells and tissues. The invention more specifically relates to antibodies that are immunologically specific for a particular human protein, ARL-1 (also referred to as AKR1B10), a species of protein in the aldo-keto reductase (AKR) superfamily. The invention particularly relates to polyclonal antisera, monoclonal antibodies and fragments and derivatives thereof that are immunologically specific for ARL-1 differentially expressed in normal and tumor or precancerous cells and tissues of the gastrointestinal tract.

    • Extended Technology Summary [PDF]
  • ARL-1 Specific Antibodies and Uses Thereof
    • Issued 4/1/2014 as US Pat #8,685,666

      Inventor: Deliang Cao

      Summary: ARL-1 expression can be detected in certain normal tissues or certain cancerous tissues, particularly in human gastrointestinal tissues (such as stomach, small intestine or colon), liver, lung, breast, or prostate, using an ARL-1-specific antibody. Thus, the invention provides methods for detecting ARL-1 protein in a normal or cancerous tissue sample, particularly a liver, lung, breast, or prostate tissue sample.

    • Extended Technology Summary [PDF]
  • Camera System for Video Assisted Thoracic Surgery
    • Filed 4/5/2019 as US Pat #16/376,551

      Inventors: Traves Crabtree, Timothy York, Mitchell McKay, and Mingshao Zhang

      Summary: SIU researchers have developed a multifunctional camera system having a bendable arm and camera configured to be inserted into the thoracic cavity of a patient. The camera head has a high definition video camera, light source and a view adjustment mechanism for changing the viewing angle of the camera without changing the position of the camera head. A controller controls the view adjustment mechanism under the command of a surgeon.

    •  Extended Technology Summary [PDF]
  • Dental Repair Material
    • Issued 5/7/2013 as US Pat #8,436,071

      Inventors: John Hatton, Benjamin Ber, and Gregory Stewart

      Summary: This technology relates to the surprising discovery that the addition of divalent-cationic halogen salt and derivatives of cellulose polymers to dental repair compounds results in dental repair compositions having improved handling properties, which enables more effective treatment of various indications of use. Those improved handling properties include increased viscosity and shortened setting time.

    • Extended Technology Summary [PDF]
  • Genetic Selection System for Identification of microRNA Target Genes
    • Issued 10/7/2014 as US Pat #8,852,926

      Inventors: Yin-Yuan Mo and Fangting Wu

      Summary: miRNA target determination largely relies on computer-aided algorithms based on the nucleotide base pairing of a miRNA sequence and the 3’-untranslated regions of a potential target gene. However, predicted targets vary from one program to another. Recent evidence also indicates that even perfect base pairing may not predict miRNA-target interactions. This novel system utilizes a specially constructed plasmid that contains a puromycin resistance gene, a resistance gene blocker, and cDNA for a gene of interest. The plasmid is transfected into host cells along with a vector expressing a miRNA. If the cDNA contains a miRNA target, the cells will live in the presence of puromycin. If the cDNA does not contain a miRNA target, the cells will die in the presence of puromycin. This method can be used with cDNAs and miRNAs of interest as a rapid screening tool that provides clear and measurable results. This invention could be sold either as individual plasmids or a kit and would save researchers weeks to months performing individual target validation tests.

    • Extended Technology Summary [PDF]
  • Heterogeneous Catalysts for NMR/MRI Enhancement via SABRE
    • Issued 7/18/2017 as US Pat #9,707,550

      Inventors: Boyd Goodson, Eduard Chekmenev, Fan Shi, and Aaron Coffey

      Summary: Catalysts to enhance the signal of nuclear magnetic resonance imaging using the Signal Amplification by Reversible Exchange technique. Catalysts can be injected into a patient, organism, or biological tissue to enhance signals by several orders of magnitude, allowing for faster, more accurate imaging using lower-cost imaging equipment.

  • Magnetic Induction System for Penile Prosthesis
    • Issued 2/5/2019 as US Pat #10,195,034 and filed 12/21/2018 as US Pat App #16/230,905

      Inventors: Alberto Colombo and Kevin McVary

      Summary: A means of effecting the operation of a novel penile prosthesis through a magnetic induction device is provided by this invention. The novel penile prosthesis leverages a memory shape alloy that needs to be heated to transform its shape. The heat may be induced with the correct metal and distance to the metal.

    • Extended Technology Summary [PDF]
  • Material Retrieval Device and Method of Using
    • Issued 3/29/2011 as US Pat #7,914,540

      Inventors: Bradley Schwartz, Ajay Mahajan, and Don Jarlen

      Summary: A medical device configured to be inserted into a patient's body to retrieve calculi material. When in the collapsed state, a side-facing opening may be closed so that the device may be inserted into the patient's body. While in the patient's body, the basket assembly may be transitioned to the expanded state so that the physician may maneuver material into the basket assembly via the side-facing opening. The basket assembly may later be transitioned into the collapsed state so that the basket assembly can be removed from the patient's body.

    • Extended Technology Summary [PDF]
  • Method for Creating Hyperpolarization at Microtesla Magnetic Fields
    • Filed 10/28/2015 as US Pat App #14/925,507 and 10/23/2019 as US Pat App #16/607,701

      Inventors: Warren Warren, Thomas Theis, Eduard Chekmenev, Milton Truong, Aaron Coffey, Boyd Goodson, Danila Barskiy, Roman Shchepin, and Fan Shi

      Summary: Hyperpolarization allows for enhanced magnetic imaging of patients, organisms, or biological tissue using greatly reduced magnetic field strength. This enhancement allows for faster, more accurate imagine using lower-cost equipment.

  • Methods for Diagnosing Bowel Disease
    • Issued 10/8/2013 as US Pat #8,551,720

      Inventor: Deliang Cao

      Summary: Gastrointestinal diseases, including inflammation and malignance, affect millions of people. For example, chronic ulcerative colitis and Crohn's disease affect roughly two million Americans and are often associated with the development of colorectal cancer. A determination may be made as to whether the sample comprises a bowel disease (“BD”) marker such as AKR1B10 and as to whether a patient may have a predisposition to a bowel disease using this invention.

    • Extended Technology Summary [PDF]
  • Penile Prosthesis
    • Issued 12/8/2015 as US Pat #9,204,966 (owned by Northwestern University, but jointly administered with SIU)

      Inventors: Brian Le, David Dunand, Alberto Colombo, and Kevin McVary

      Summary: This invention relates to a novel penile prosthesis that utilizes a memory shape alloy to assist with erectile dysfunction.  The prosthesis is implanted into the corpus cavernosum to expand cross-sectionally and straighten to the erect position before or during sexual intercourse.

    • Extended Technology Summary [PDF]  
  • pH-Sensitive Imaging Agents
    • Issued 6/20/2017 as US Pat #9,682,157

      Inventors: Yong Gao and Boyd Goodson

      Summary: Surface-functionalized SPION-based agents allow for pH-sensitive contrast in magnetic resonance imagine applications. These agents feature a paramagnetic core, a linker group, and a macromolecule with pH sensitivity. A method for imaging biological tissue using such compounds is also addressed.

    • Extended Technology Summary [PDF]
  • Somatostatin Receptor Type 4 Agonist Compounds for Alzheimer's Disease
  • Thermoablation Probe
    • Issued 8/25/2020 as US Pat #10,751,123

      Inventors: Jenna Gorlewicz, Eric Leuthardt, and Mahmood Rezapour

      Summary: This technology comprises a thermoablation probe for performing an interstitial thermal therapy (ITT) procedure on a brain lesion. This technology solves the problem of treating peripheral regions of the lesion that are offset from the linear path of deployment beyond the range of the probe’s radiant energy.

    • Extended Technology Summary [PDF]
  • Tuning CRISPR/Cas9 Activity with Chemically Modified Nucleotide Substitutions
    • Filed 2/22/2019 as US Pat App #16/327,605 with complementary filing in Canada

      Inventors: Keith Gagnon , Elise Malek-Adamian, Maryam Habibian, Daniel O'Reilly, Zachery Kartje, and Masad Damha

      Summary: Cleavage efficiency, kinetics and stability of CRISPR-Cas9 are tuned by chemical modification of RNA nucleotides in the ribonucleoprotein complex. Selection of appropriate modifications and substitution positions can significantly increase cleavage activity, specificity and rates and also eliminate the need for RNA bases while maintaining cleavage. This invention allows for precise control over the activity of CRISPR-Cas enzyme systems. Certain chemical modifications can substantially reduce the cost of RNA synthesis and implementation of CRISPR-Cas editing technologies while also enabling practical use in therapeutic applications.

    • Extended Technology Summary [PDF]
  • Water Solubule Catalysts for NMR/MRI Enhancement
    • Issued 10/17/2017 as US Pat #9,790,245

      Inventors: Eduard Chekmenev, Boyd Goodson, Milton Truong, Ping He, Quinn Best, Fan Shi, Kirsten Groome, and Aaron Coffey

      Summary: Water-soluble catalysts to enhance the signal of nuclear magnetic resonance imaging in biological media. Catalysts can be injected into a patient, organism, or biological tissue to enhance signals by several orders of magnitude, allowing for faster, more accurate imaging using lower-cost imaging equipment.


SIU's innovative faculty, staff, and student researchers include world-class experts in hundreds of distinct research areas. Select technologies are featured below. Contact us for more information on partnering with SIU or licensing available technologies or processes.

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SIU partners with companies and other institutions across the world in guided discovery initiatives and other projects. Contact us to connect with SIU researchers who may be interested in collaborating or performing sponsored research in an area not identified above.