The SIU System maintains multiple offices that support the activities of the universities.
- Academic Innovation, Planning, and Partnership
- Center for Rural Health and Social Service Development
- Financial and Administrative Affairs
- Anti-racism, Diversity, Equity and Inclusion
- Ethics
- Export Controls
- General Counsel
- Internal Audit
- Office of Community Engagement
- Risk Management Insurance Programs
- Tax Compliance
- Technology Management & Industry Relations
- Governmental and Public Affairs
